Paul Pogba and Anthony Martial have been ruled out of Manchester United's Premier League clash against Leicester City on Saturday, with manager Ole Gunnar Solskjaer saying he could be without seven senior players for the game.
Pogba (ankle) and Anthony Martial (muscle injury) are also expected to miss Thursday's Europa League encounter with Astana, while Diogo Dalot (hip), Luke Shaw (hamstring) and Eric Bailly (knee) are also due to miss the Leicester clash.
And Solskjaer, whose United team have made the club's worst start to a season in 27 years, said he could also be without Aaron Wan-Bissaka (back) and Jesse Lingard (illness) following their withdrawals from Gareth Southgate's England squad last week.
"The treatment room been busy and still is," Solskjaer said. "I don't really know who will be available.
"Maybe Aaron, maybe Jesse. But that's it, from the ones who have pulled out. I can't promise they'll be available either.
"Pogba won't be fit unless he has had a miraculous recovery overnight or before the game. He has not been ready to do 100% training.
"We hope more can be ready for West Ham next week and Paul and Anthony are in that category. I think they'll be ready for then, I can't say more really.
"But you have players who can come in with loads of experience -- Juan [Mata], Nemanja [Matic], Ash [Young]. They are the ones who have to step up now."
Leicester have started the season unbeaten and face United sitting third in the table.
And Solskjaer admits that Brendan Rodgers's team will a stern challenge to his injury-hit team.
"Leicester want to push into the top four," Solskjaer said. "They have got good players and a very good manager.
"Brendan's teams always play good football and we need to play good football to get three points."