Prime-time Parlay: FPI predictions for the biggest games of NFL Week 10

Will Jared Goff and the Rams bounce back against the Seahawks after loss No. 1 ? Gregory Shamus/Getty Images

The NFC West takes the spotlight in this week's Prime-time Parlay, with the key Rams-Seahawks battle in Los Angeles and a Monday night contest including quarterback Nick Mullens and the 49ers versus the Giants (ESPN, 8:15 p.m. ET) among Week 10's most visible games. Will this be the week PTP cashes in?

Once again, Prime-time Parlay is all about the best games: Thursday, Sunday and Monday's prime-time games and the top 1 p.m. ET and 4 p.m. ET Sunday matchups. Straight-up picks, but you gotta hit all five. Then we calculate how much you'd earn for the parlay, using Westgate's money lines.

Via ESPN's Football Power Index, Prime-time Parlay tells you the analytics-based predictions for the meetings of greatest national import, offering the smart picks for the games you'll be watching. (All NFL point spreads and money lines can be found here).

Total payout for Week 10 Prime-time Parlay (selecting all FPI-projected winners in five games): $431.17 on $100 wager

Carolina Panthers at Pittsburgh Steelers (8:20 p.m. ET Thursday, Fox/NFL Network)

Money line: Steelers -210
FPI projection: Steelers win by 5.6 points

The Panthers' and Steelers' offenses have played at a very similar level this year, but FPI thinks that Pittsburgh's is still a couple of points superior based on prior information from before the season. Though we've learned a lot this year, our preseason notions still hold some predictive value. -- Seth Walder

New Orleans Saints at Cincinnati Bengals (1 p.m. ET Sunday, Fox)

Money line: Saints -240
FPI projection: Saints win by 1.0 points

Both of these teams have above-average passing offenses and rushing offenses, from the standpoint of expected points added (EPA) per play. But the Saints also have been better than the Bengals in both areas, and a superior passing offense can go a long way (and help make up for New Orleans' defensive deficiencies). -- Seth Walder

Seattle Seahawks at Los Angeles Rams (4:25 p.m. ET Sunday, CBS)

Money line: Rams -550
FPI projection: Rams win by 9.9 points

You think Sean McVay is going to drop two in a row? The Rams' league-best pass block win rate will give Jared Goff all day to throw against a subpar Seahawks pass rush. -- Seth Walder

Dallas Cowboys at Philadelphia Eagles (8:20 p.m. ET Sunday, NBC)

Money line: Eagles -310
FPI projection: Eagles win by 8.5 points

Just think: FPI feels this good about Philly, and it doesn't even know about the Golden Tate addition. A rested Eagles team should be able to handle Dallas. -- Seth Walder

New York Giants at San Francisco 49ers (8:15 p.m. ET Monday, ESPN)

Money line: 49ers -160
FPI projection: 49ers win by 2.1 points

Nick Mullens doesn't have to be the savior; he just has to be better than Eli Manning. At this point, how hard is that? If Manning is outdueled by the Southern Miss alum, it could be Kyle Lauletta time in New York. -- Seth Walder

Final Parlay: Steelers, Saints, Rams, Eagles, 49ers

For more from ESPN Analytics, visit the ESPN Analytics Index.