Wigginton, who withdrew from last year's draft at the last minute after a spectacular freshman season, announced his plans Thursday on Twitter.
Wigginton's numbers dipped a bit last season after a foot injury cost him 10 non-conference games. But Wigginton still averaged 13.5 points and 4.1 rebounds per game off the bench while shooting 40 percent on 3-pointers.
He joins freshman Talen Horton-Tucker as Cyclones who have declared for the draft. Wigginton's decision will likely push Tyrese Haliburton into the starting role at point guard -- and it could also put Iowa State in the market for a graduate transfer backcourt player.