Georgia Southern (14-9, 6-4 Sun Belt Conference) shot 54 percent from the floor, 35 of 65, and drained 10 of 15 shots from behind the 3-point arc.
Brown, with three, and Jackson, with four, combined for the bulk of the Eagles 3-pointers. The pair nailed consecutive treys to break an early tie, giving Georgia Southern a 13-6 lead. The lead grew as large as 17 points for a 51-38 advantage at the half.
The Eagles opened the second half on a 9-3 pace, including 3-pointers by Calvin Wishart and Brown, and were up by as many as 25.
The Eagles, who remain in a tight bunch with the top five teams in the Sun Belt, scored the most points in a conference game since 2005.
The Ragin' Cajuns (13-10, 4-6) have lost their third in a row, giving up 104, 96 and 103 points.
Path gets no easier for Minnesota: No. 3 Ohio State is next
Minnesota coach Richard Pitino hopes the fans get behind the Golden Gophers when they host No. 3 Ohio State in Minneapolis on Sunday.
Scott carries Loyola Marymount over Prairie View 79-76
Eli Scott and Ivan Alipiev each scored 17 points as Loyola Marymount beat Prairie View 79-76 on Friday night.
Tryon carries Portland over Evergreen State 77-55
Jacob Tryon had 10 points and 11 rebounds to lead Portland to a 77-55 win over Evergreen State on Friday night.