The Jaguars (3-3, 2-0 Southwest Athletic Conference) beat the Panthers (2-4, 1-1) for a fourth straight time.
Southern took a 14-7 lead into halftime, but Prairie View's Jaylen Harris picked off a Skelton pass and returned it 35 yards for a touchdown to pull the Panthers even at 14-all in the third quarter.
Southern regained the lead on Cesar Barajas' 44-yard field goal and then stretched its advantage to 31-21 on Skelton's TD run following the blocked punt.
The Panthers got within three points on Tony Mullins' 5-yard TD run, but Skelton led a long drive that was capped by a Barajas field goal to wrap up the win for the Jaguars.
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Saban not focusing on loss to LSU
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Nick Saban says Alabama focused on this week, not playoff scenarios
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